NVP-BHG712

NVP-BHG712 is an oral active EphB4 kinase autophosphorylation inhibitor, with IC50 values of 3.3 nM and 3.0 nM for EphA2 and EphB4, respectively[1][2].

Product Specifications

CAS Number

[940310-85-0]

Product Name Alternative

BHG712

UNSPSC

12352005

Hazard Statement

H301

Target

Ephrin Receptor

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nvp-bhg712.html

Purity

99.71

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1NC2=NC(C3=CC=CN=C3)=NC4=C2C=NN4C)C(NC5=CC=CC(C(F)(F)F)=C5)=O

Molecular Formula

C26H20F3N7O

Molecular Weight

503.48

Precautions

H301

References & Citations

[1]Tröster A, et al. NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem. 2018 Aug 20;13 (16) :1629-1633.|[2]Martiny-Baron G, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13 (3) :259-67.