Vosoritide (acetate)
Vosoritide (BMN 111) acetate is a natriuretic peptide receptor 2 (NPR2) agonist that acts on the proliferation and differentiation of chondrocytes to promote bone growth[1].
Product Specifications
Product Name Alternative
BMN 111 (acetate)
UNSPSC
12352209
Target
FGFR
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vosoritide-acetate.html
Purity
99.96
Solubility
H2O : ≥ 100 mg/mL
Smiles
CC[C@@H]([C@H]1C(NCC(N[C@@H](CO)C(N[C@@H](CCSC)C(N[C@@H](CO)C(NCC(N[C@@H](CC(C)C)C(NCC(N[C@H](C(O)=O)CSSC[C@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H]3CCCN3)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)CC4=CN=CN4)=O)=O)CC(N)=O)=O)C)=O)CCCNC(N)=N)=O)CCCCN)=O)CC5=CC=C(O)C=C5)=O)CCCCN)=O)=O)C)=O)CC(N)=O)=O)CCCCN)=O)CCCCN)=O)=O)CC(C)C)=O)CO)=O)CCCCN)=O)=O)C(N[C@@H](CC6=CC=CC=C6)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C.O=C(C)O
Molecular Formula
C176H290N56O51S3.C2H4O2
Molecular Weight
4162.78
References & Citations
[1]Leia C. Shuhaibar, et al. Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. JCI Insight. 2021 May 10;6 (9) :e141426.|[2]Shuhaibar LC, et al. Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth. JCI Insight. 2021 May 10;6 (9) :e141426.|[3]Lorget F, et al. Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am J Hum Genet. 2012 Dec 7;91 (6) :1108-14.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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