Dihydroergocristine (mesylate) (Standard)

Dihydroergocristine (mesylate) (Standard) is the analytical standard of Dihydroergocristine (mesylate) . This product is intended for research and analytical applications. Dihydroergocristine mesylate (DHEC mesylate) is a inhibitor of γ-secretase (GSI), reduces the production of the Alzheimer's disease amyloid-β peptides, binds directly to γ-secretase and Nicastrin with equilibrium dissociation constants (Kd) of 25.7 nM and 9.8 μM, respectively[1].

Product Specifications

CAS Number

[24730-10-7]

Product Name Alternative

DHEC (mesylate) (Standard)

UNSPSC

12352005

Target

Amyloid-β; Reference Standards

Type

Reference Standards

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dihydroergocristine-mesylate-standard.html

Smiles

O[C@@]([C@@](CCC1)([H])N1C2=O)(O[C@](NC([C@@H](CN(C)[C@]3([H])C4)C[C@]3([H])C5=C6C4=CNC6=CC=C5)=O)(C(C)C)C7=O)N7[C@H]2CC8=CC=CC=C8.CS(=O)(O)=O

Molecular Formula

C36H45N5O8S

Molecular Weight

707.84

References & Citations

[1]Lei X, et al. The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides. Sci Rep. 2015 Nov 16;5:16541.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Clinical Information

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