K-Ras-IN-1

K-Ras-IN-1 is the inhibitor for K-Ras by occupying the binding site of son of sevenless (Sos), preventing the interaction between Sos and K-Ras, inhibiting the Sos-catalyzed GDP to GTP exchange process. K-Ras-IN-1 is promising for research of pancreatic, colon and lung cancer[1][2].

Product Specifications

CAS Number

[84783-01-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/K-Ras-IN-1.html

Purity

98.00

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(C1=CC=CC=C1O)N2CCCC2

Molecular Formula

C11H13NOS

Molecular Weight

207.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Hocker HJ, et al. LIBSA--a method for the determination of ligand-binding preference to allosteric sites on receptor ensembles. J Chem Inf Model. 2014 Feb 24;54 (2) :530-538.|[2]Sun Q, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl. 2012 Jun 18;51 (25) :6140-3.