αvβ1 integrin-IN-1
αvβ1 integrin-IN-1 (Compound C8) is a potent and selective αvβ1 integrin inhibitor with an IC50 of 0.63 nM. Antifibrotic effects[1].
Product Specifications
CAS Number
[1689540-62-2]
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/αvβ1-integrin-in-1.html
Concentration
10mM
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](CC1=CC=C(NC(CCCCNC(N)=N)=O)C=C1)NC([C@H]2N(S(=O)(C3=CC=CC=C3)=O)CCC2)=O
Molecular Formula
C26H34N6O6S
Molecular Weight
558.65
References & Citations
[1]Reed NI, et al. Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors. ACS Med Chem Lett. 2016 Aug 30;7 (10) :902-907.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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