Antitumor agent-149
Product Specifications
UNSPSC Description
Antitumor agent-149 (Compound 3) is an analogue of Echinomycin (HY-106101). Antitumor agent-149 inhibits HIF-1α-mediated transcription. Antitumor agent-149 induces cancer cell apoptosis. Antitumor agent-149 inhibits tumor growth in SW620 xenograft mice model[1].
Target Antigen
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-149.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(N[C@H](C(N([C@@H](CSC1)C(N([C@H]2C(C)C)C)=O)C)=O)C)=O)COC([C@H](C(C)C)N(C([C@H]1N(C([C@H](C)NC([C@H](NC(C3=NC(C=CC=C4)=C4C=C3O)=O)COC2=O)=O)=O)C)=O)C)=O)C5=NC(C=CC=C6)=C6C=C5O
Molecular Weight
1085.19
References & Citations
[1]Kojima K, et al. Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent. Sci Rep. 2024 Apr 1;14(1):7628.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161425/Antitumor-agent-149-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161425/
Clinical Information
No Development Reported
CAS Number
9007-83-4
Curated Selection
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