DCVC

DCVC (S-[ (1E) -1,2-Dichloroethenyl]-L-cysteine) is a bioactive metabolite of trichloroethylene (TCE) . DCVC inhibits pathogen-stimulated pro-inflammatory cytokines IL-1β, IL-8, and TNF-α release from tissue cultures[1][2].

Product Specifications

CAS Number

[13419-46-0]

Product Name Alternative

S-[ (1E) -1,2-Dichloroethenyl]-L-cysteine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/DCVC.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 2.5 mg/mL (ultrasonic) |H2O : 1.034 mg/mL (ultrasonic; warming)

Smiles

N[C@H](C(O)=O)CS/C(Cl)=C\Cl

Molecular Formula

C5H7Cl2NO2S

Molecular Weight

216.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Boldenow E, et al. The trichloroethylene metabolite S- (1,2-dichlorovinyl) -l-cysteine but not trichloroacetate inhibits pathogen-stimulated TNF-α in human extraplacental membranes in vitro. Reprod Toxicol. 2015 Apr;52:1-6.|[2]Lash LH, et al. Multigenerational study of chemically induced cytotoxicity and proliferation in cultures of human proximal tubular cells. Int J Mol Sci. 2014 Nov 18;15 (11) :21348-65.