L 646462
L-646462 is an antagonist of dopamine and 5-HT, with selectivity for the peripheral system (the central/peripheral activity ratio of L-646462 is 143) . L-646462 can be used in research related to nausea, vomiting, and associated neurological disorders[1].
Product Specifications
CAS Number
89149-85-9
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-646462.html
Smiles
O=C(C1=CC=C2C(/C(C3=CC=CC=C3C=C2)=C4CCN(C)CC/4)=C1)OCN(C(N(C)C5)=O)C5=O
Molecular Formula
C27H27N3O4
Molecular Weight
457.52
References & Citations
[1]Williams M, et al. L-646,462, a cyproheptadine-related antagonist of dopamine and serotonin with selectivity for peripheral systems[J]. Journal of Pharmacology and Experimental Therapeutics, 1984, 229 (3) : 775-781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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