MK-3577
MK-3577 is an orally effective glucagon receptor (GCGR) antagonist that reduces hepatic glucose production and lowers blood glucose levels by blocking glucagon receptors on target organs, primarily the liver. Pharmacokinetic analysis in domestic cats indicates that MK-3577 reaches peak levels 3 to 4 hours after oral administration, with a half-life of approximately 15 hours. MK-3577 can be used in diabetes research[1].
Product Specifications
CAS Number
1019112-29-8
UNSPSC
12352005
Target
GCGR
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-3577.html
Smiles
CCC[C@H](C1=CC=C(C=C1)C(NCCC(O)=O)=O)[C@H](C2=CC=C(C=C2)Cl)C(C3=CC(C)=C4)=CNC3=C4F
Molecular Formula
C30H30ClFN2O3
Molecular Weight
521.02
References & Citations
[1]Mott J, et al. The glucagon-receptor antagonist MK-3577 reduces glucagon-stimulated plasma glucose and insulin concentrations in metabolically healthy overweight cats. Domest Anim Endocrinol. 2024 Oct;89:106874.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Frequently Asked Questions
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