CP-99994 (hydrochloride)
CP-99994 hydrochloride is a Tachykinin neurokinin 1 (NK-1) receptor antagonist with a Ki of 0.25 nM. CP-99994 hydrochloride prevents colorectal sensitization in the context of visceral hypersensitivity. CP-99994 hydrochloride reduces colorectal hypersensitivity induced by acetic acid injections in a model of bladder-colon cross-sensitization. CP-99994 hydrochloride attenuates the neuroglial interactions and MAPK-p38 phosphorylation associated with visceral hypersensitivity[1].
Product Specifications
CAS Number
[145148-39-6]
UNSPSC
12352005
Hazard Statement
H410
Target
Endogenous Metabolite; Neurokinin Receptor; p38 MAPK
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cp-99994-hydrochloride.html
Smiles
COC(C=CC=C1)=C1CN[C@@H]2[C@H](C3=CC=CC=C3)NCCC2.Cl.Cl
Molecular Formula
C19H26Cl2N2O
Molecular Weight
369.33
Precautions
P273-P391-P501
References & Citations
[1]Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NK1R
Available Sizes
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