NALP4 rabbit pAb
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e. g. CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al. 2003 [PubMed 12563287]). [supplied by OMIM, Mar 2008],
Product Specifications
Background
UniProt
Q96MN2
Swiss Prot
Q96MN2
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human NALP4 AA range: 307-357
Target
NALP4
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytosol, extracellular exosome
Gene ID (Human)
147945
Available Sizes
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