Pneumocandin B0
Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis[1][2][3].
Product Specifications
CAS Number
135575-42-7
Product Name Alternative
L-688786
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Intermediate
Type
Natural Products
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/pneumocandin-b0.html
Purity
96.54
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@](NC(C(NC([C@@](C[C@@H](O)C1)([H])N1C2=O)=O)[C@H](O)[C@H](C3=CC=C(O)C=C3)O)=O)([H])[C@H](O)CC(N)=O)N4[C@@](C(N[C@@H]([C@@H](C[C@@H](C(NC2[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)O)=O)([H])[C@@H](O)CC4
Molecular Formula
C50H80N8O17
Molecular Weight
1065.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Welch CJ, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101 (1-2) :204-13.|[2]Leonard WR Jr, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. J Org Chem. 2007 Mar 30;72 (7) :2335-43.|[3]Song P, et al. Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains. J Ind Microbiol Biotechnol. 2018 Sep;45 (9) :767-780.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
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