Pneumocandin B0

Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006) . Pneumocandin B0 can be isolated from fungus Glarea lozoyensis[1][2][3].

Product Specifications

CAS Number

[135575-42-7]

Product Name Alternative

L-688786

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/pneumocandin-b0.html

Purity

96.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@](NC(C(NC([C@@](C[C@@H](O)C1)([H])N1C2=O)=O)[C@H](O)[C@H](C3=CC=C(O)C=C3)O)=O)([H])[C@H](O)CC(N)=O)N4[C@@](C(N[C@@H]([C@@H](C[C@@H](C(NC2[C@H](O)C)=O)NC(CCCCCCCC[C@@H](C)C[C@@H](C)CC)=O)O)O)=O)([H])[C@@H](O)CC4

Molecular Formula

C50H80N8O17

Molecular Weight

1065.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Welch CJ, et al. Preparation and evaluation of novel stationary phases for improved chromatographic purification of pneumocandin B0. J Chromatogr A. 2006 Jan 6;1101 (1-2) :204-13.|[2]Leonard WR Jr, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. J Org Chem. 2007 Mar 30;72 (7) :2335-43.|[3]Song P, et al. Metabolomics profiling reveals the mechanism of increased pneumocandin B0 production by comparing mutant and parent strains. J Ind Microbiol Biotechnol. 2018 Sep;45 (9) :767-780.