C-Met/HDAC-IN-4
C-Met/HDAC-IN-4 is a dual inhibitor of c-Met/HDAC. The IC50 value of c-Met/HDAC-IN-4 for c-Met is 28.92 nM. c-Met/HDAC-IN-4 can induce G0/G1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells, and it inhibits the proliferation and invasion of breast cancer cell lines[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-hdac-in-4.html
Smiles
NC1=CC=CC=C1NC(/C=C/C2=CC=C(CN3CCN(C4=CC=C(N=NN5C(C6=CC=C(N=CC=C7)C7=C6)C)C5=C4)CC3)C=C2)=O
Molecular Formula
C37H36N8O
Molecular Weight
608.73
References & Citations
[1]Wang Z, et al. Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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