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C-Met/HDAC-IN-4

C-Met/HDAC-IN-4 is a dual inhibitor of c-Met/HDAC. The IC50 value of c-Met/HDAC-IN-4 for c-Met is 28.92 nM. c-Met/HDAC-IN-4 can induce G0/G1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells, and it inhibits the proliferation and invasion of breast cancer cell lines[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; c-Met/HGFR; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-met-hdac-in-4.html

Smiles

NC1=CC=CC=C1NC(/C=C/C2=CC=C(CN3CCN(C4=CC=C(N=NN5C(C6=CC=C(N=CC=C7)C7=C6)C)C5=C4)CC3)C=C2)=O

Molecular Formula

C37H36N8O

Molecular Weight

608.73

References & Citations

[1]Wang Z, et al. Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer[J]. ACS Medicinal Chemistry Letters, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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