Wy-45494 (hydrochloride)
Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively) . In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Product Specifications
CAS Number
[93413-90-2]
Product Name Alternative
N-Desmethyl Venlafaxine (hydrochloride) ; Wy 45494
UNSPSC
12352005
Hazard Statement
H336
Target
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/wy-45494-hydrochloride.html
Purity
99.65
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
OC1(C(C2=CC=C(OC)C=C2)CNC)CCCCC1.[H]Cl
Molecular Formula
C16H26ClNO2
Molecular Weight
299.84
Precautions
H336
References & Citations
[1]Otton, et al. Venlafaxine oxidation in vitro is catalysed by CYP2D6. Br. J. Clin. Pharmacol. 41 (2), 149-156 (1996) .
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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