PAR4 antagonist 8
Product Specifications
UNSPSC Description
PAR4 antagonist 8 (Compound 20f) is an effective, orally active, and selective PAR4 antagonist with an IC50 value of 15.32 nM. PAR4 antagonist 8 exhibits favorable pharmacokinetic properties. PAR4 antagonist 8 not only effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50 = 6.39 nM) but also inhibits mouse platelet aggregation. PAR4 antagonist 8 can be used in antithrombotic research[1].
Target Antigen
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-8.html
Smiles
COC1=NC2=CC(C)=CC(C3=NC4=C(S3)C(C[C@@H](O5)COC(NC6=CC(F)=CC(C#N)=C6)=O)=C5C(F)=C4)=C2C=N1
Molecular Weight
559.54
References & Citations
[1]Li S, et al. Discovery of quinazoline-benzothiazole derivatives as novel potent protease-activated receptor 4 antagonists with improved pharmacokinetics and low bleeding liability[J]. European Journal of Medicinal Chemistry, 2024, 280: 116980.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159896/PAR4-antagonist-8-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159896/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7145731 Inquire
Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) IQM5 Polyclonal Antibody
Ask
View Details