PAR4 antagonist 8
PAR4 antagonist 8 (Compound 20f) is an effective, orally active, and selective PAR4 antagonist with an IC50 value of 15.32 nM. PAR4 antagonist 8 exhibits favorable pharmacokinetic properties. PAR4 antagonist 8 not only effectively inhibits human platelet aggregation induced by PAR4 agonists (IC50 = 6.39 nM) but also inhibits mouse platelet aggregation. PAR4 antagonist 8 can be used in antithrombotic research[1].
Product Specifications
UNSPSC
12352005
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/par4-antagonist-8.html
Smiles
COC1=NC2=CC(C)=CC(C3=NC4=C(S3)C(C[C@@H](O5)COC(NC6=CC(F)=CC(C#N)=C6)=O)=C5C(F)=C4)=C2C=N1
Molecular Formula
C28H19F2N5O4S
Molecular Weight
559.54
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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