GSK-843

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation[1][2].

Product Specifications

CAS Number

[1601496-05-2]

Product Name Alternative

GSK'843

UNSPSC

12352005

Target

Apoptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk-843.html

Purity

99.18

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

NC1=NC=C(C2=CC(C)=NN2C)C3=C1C(C4=CC=C(SC=N5)C5=C4)=CS3

Molecular Formula

C19H15N5S2

Molecular Weight

377.49

References & Citations

[1]Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56 (4) :481-95.|[2]Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288 (43) :31268-79.