Thanatin

Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2].

Product Specifications

CAS Number

[214542-43-5]

UNSPSC

12352209

Target

Bacterial; Fungal

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/thanatin.html

Purity

98.40

Solubility

H2O : ≥ 100 mg/mL

Smiles

NCC(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H](C(C)C)C(N2[C@@H](CCC2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(N[C@@H]3C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC(N[C@H](C(N[C@@H](CSSC3)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCSC)=O)=O)=O)=O)CCCCN)=O)=O)([H])[C@H](O)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(N)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C103H177N35O27S3

Molecular Weight

2433.92

References & Citations

[1]Rachita Dash, et al. Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action. Int J Mol Sci. 2021 Feb 3;22 (4) :1522. |[2]Bo Ma, et al. The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase. Nat Commun. 2019 Aug 6;10 (1) :3517.