FPR2 agonist 3
FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the STAT3/SOCS3 signaling pathway[1].
Product Specifications
CAS Number
2829263-19-4
UNSPSC
12352005
Target
Formyl Peptide Receptor (FPR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fpr2-agonist-3.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC=C(NC(N[C@@H](CC2=CC=C(C#N)C=C2)C(N3C(C=C(F)C=C4)=C4CC3)=O)=O)C=C1
Molecular Formula
C25H20F2N4O2
Molecular Weight
446.45
References & Citations
[1]Jie Zang, et al. Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors. J Med Chem. 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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