(R) -GSK866

(R) -GSK866 ((R) -GSK47866A) is the (R) -enantiomer of GSK866 (HY-157294) . GSK866 is a selective agonist for glucocorticoid receptor with an IC50 of 4.6 nM[1].

Product Specifications

CAS Number

[1094607-80-3]

Product Name Alternative

(R) -GSK47866A

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-gsk866.html

Purity

98.0

Smiles

NC1=C(C(NC[C@@](C(F)(F)F)(O)CN(CC)C(C2=C(C=CC=C2Cl)Cl)=O)=O)C=NN1C3=CC=C(C=C3)F

Molecular Formula

C23H21Cl2F4N5O3

Molecular Weight

562.34

References & Citations

[1]Chandra S Chirumamilla, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1:8:1324.