(R) -GSK866
(R) -GSK866 ((R) -GSK47866A) is the (R) -enantiomer of GSK866 (HY-157294) . GSK866 is a selective agonist for glucocorticoid receptor with an IC50 of 4.6 nM[1].
Product Specifications
CAS Number
[1094607-80-3]
Product Name Alternative
(R) -GSK47866A
UNSPSC
12352005
Target
Glucocorticoid Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-gsk866.html
Purity
98.0
Smiles
NC1=C(C(NC[C@@](C(F)(F)F)(O)CN(CC)C(C2=C(C=CC=C2Cl)Cl)=O)=O)C=NN1C3=CC=C(C=C3)F
Molecular Formula
C23H21Cl2F4N5O3
Molecular Weight
562.34
References & Citations
[1]Chandra S Chirumamilla, et al. Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads. Front Immunol. 2017 Nov 1:8:1324.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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