Chelidonine

Chelidonine, an isoquinoline alkaloid, can be isolated from Chelidonium majus L.. Chelidonine causes G2/M arrest and induces caspase-dependent and caspase-independent apoptosis, and prevents cell cycle progression of stem cells in Dugesia japonica. Chelidonine has cytotoxic activity against melanoma cell lines. with anticancer and antiviral activity[1][2][3].

Product Specifications

CAS Number

[476-32-4]

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Apoptosis; Influenza Virus

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/chelidonine.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CN1[C@@]2([H])[C@@]([C@H](CC3=C2C=C4C(OCO4)=C3)O)([H])C5=C(C6=C(OCO6)C=C5)C1

Molecular Formula

C20H19NO5

Molecular Weight

353.37

Precautions

H302+H312+H332

References & Citations

[1]Lee YK, et al. Chelidonine Induces Caspase-Dependent and Caspase-Independent Cell Death through G2/M Arrest in the T98G Human Glioblastoma Cell Line. Evid Based Complement Alternat Med. 2019 May 26;2019:6318179.|[2]Isolani ME, et al. The in vivo effect of chelidonine on the stem cell system of planarians. Eur J Pharmacol. 2012 Jul 5;686 (1-3) :1-7.|[3]Hammerová J, et al. Benzo[c]phenanthridine alkaloids exhibit strong anti-proliferative activity in malignant melanoma cells regardless of their p53 status. J Dermatol Sci. 2011 Apr;62 (1) :22-35.