GPX4-IN-3
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM[1].
Product Specifications
CAS Number
[2761004-85-5]
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-in-3.html
Purity
99.83
Solubility
DMSO : 67.5 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CSC2=CC=CC=C21)N(C3=CC=C(C=C3)C4=CN=CO4)C(CCl)=O)NCCC5=CC=CC=C5
Molecular Formula
C29H24ClN3O3S
Molecular Weight
530.04
References & Citations
[1]Congjun Xu, et al. Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. J Med Chem. 2021 Sep 23;64 (18) :13312-13326.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal Stanniocalcin 2/STC-2 Antibody [Janelia Fluor 549]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
NBP3-00170JF549 0.1 mL
Rabbit Polyclonal Stanniocalcin 2/STC-2 Antibody [Janelia Fluor 549]
Ask
View Details 
MBS6391978-01 0.1 mL
RALGPS2 (Ras-specific Guanine Nucleotide-releasing Factor RalGPS2, RalA Exchange Factor RalGPS2, Ral GEF with PH Domain and SH3-binding Motif 2, FLJ10244, FLJ25604) (PE)
Ask
View Details MBS6391978-02 5x 0.1 mL
RALGPS2 (Ras-specific Guanine Nucleotide-releasing Factor RalGPS2, RalA Exchange Factor RalGPS2, Ral GEF with PH Domain and SH3-binding Motif 2, FLJ10244, FLJ25604) (PE)
Ask
View Details 