Deserpidine

Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex[1][2][3].

Product Specifications

CAS Number

[131-01-1]

Product Name Alternative

Harmonyl

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE)

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/deserpidine.html

Purity

98.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC([C@H]1[C@@]2([H])C[C@]3([H])C4=C(CCN3C[C@@]2([H])C[C@@H](OC(C5=CC(OC)=C(OC)C(OC)=C5)=O)[C@@H]1OC)C6=CC=CC=C6N4)=O

Molecular Formula

C32H38N2O8

Molecular Weight

578.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68 (11) :1629-31.|[2]Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877 (27) :3221-5.|[3]Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35 (14) :2558-62.