BML-288

BML-288 (compound Oxindole 1) is a potent PDE2 inhibitor with an IC50 value of 40 nM. BML-288 has the potential for the research of osteoarthritis pain[1].

Product Specifications

CAS Number

[851681-89-5]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bml-288.html

Smiles

O=C(C1C(N(C)C2=C1C=C(OC=C3)C3=C2)=O)NC4=NN=CS4

Molecular Formula

C14H10N4O3S

Molecular Weight

314.32

References & Citations

[1]Plummer MS, et al. Discovery of potent, selective, bioavailable phosphodiesterase 2 (PDE2) inhibitors active in an osteoarthritis pain model, part I: transformation of selective pyrazolodiazepinone phosphodiesterase 4 (PDE4) inhibitors into selective PDE2 inhibitors. Bioorg Med Chem Lett. 2013 Jun 1;23 (11) :3438-42.