RG13022
RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor with an IC50 of 4 μM.
Product Specifications
CAS Number
136831-48-6
Product Name Alternative
Tyrphostin RG13022
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RG13022.html
Purity
96.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#C/C(C1=CC=CN=C1)=C/C2=CC=C(OC)C(OC)=C2
Molecular Formula
C16H14N2O2
Molecular Weight
266.29
Precautions
H302, H315, H319, H335
References & Citations
[1]Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51 (16) :4430-5.|[2]Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52 (13) :3636-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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