RG13022

RG13022 is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor with an IC50 of 4 μM.

Product Specifications

CAS Number

[136831-48-6]

Product Name Alternative

Tyrphostin RG13022

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/RG13022.html

Purity

96.74

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

N#C/C(C1=CC=CN=C1)=C/C2=CC=C(OC)C(OC)=C2

Molecular Formula

C16H14N2O2

Molecular Weight

266.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51 (16) :4430-5.|[2]Reddy KB, et al. Inhibition of breast cancer cell growth in vitro by a tyrosine kinase inhibitor. Cancer Res. 1992 Jul 1;52 (13) :3636-41.