Nitecapone

Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].

Product Specifications

CAS Number

[116313-94-1]

Product Name Alternative

OR-462

UNSPSC

12352005

Hazard Statement

H301

Target

COMT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nitecapone.html

Concentration

10mM

Purity

99.32

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O

Molecular Formula

C12H11NO6

Molecular Weight

265.22

Precautions

H301

References & Citations

[1]Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462) . Free Radic Biol Med. 1992 Nov;13 (5) :517-25.|[2]Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34 (3) :531-541.|[3]Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15 (7) :732-40.