Nitecapone
Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].
Product Specifications
CAS Number
116313-94-1
Product Name Alternative
OR-462
UNSPSC
12352005
Hazard Statement
H301
Target
COMT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nitecapone.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O
Molecular Formula
C12H11NO6
Molecular Weight
265.22
Precautions
H301
References & Citations
[1]Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462) . Free Radic Biol Med. 1992 Nov;13 (5) :517-25.|[2]Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34 (3) :531-541.|[3]Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15 (7) :732-40.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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