FT206

FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM[1][2].

Product Specifications

CAS Number

[2278274-34-1]

UNSPSC

12352005

Target

Deubiquitinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ft206.html

Purity

98.40

Solubility

DMSO : 150 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C2=CC=C(C)N=C2S1)N)N[C@@H]3CC4=CC=C(N5CC6NC(CC6)C5)C=C4CC3

Molecular Formula

C25H29N5OS

Molecular Weight

447.60

References & Citations

[1]WO2020033707|[2]Diep YN, et al., Astrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloid. Biomater Res. 2023 Jul 19;27 (1) :71.|[3]Ruiz EJ, et al., USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. Elife. 2021 Oct 12;10:e71596.