FT206
FT206 is the inhibitor for ubiquitin-specific protease that inhibits USP28 and USP25 with IC50s of 0.15 μM and 1.01 μM[1][2].
Product Specifications
CAS Number
[2278274-34-1]
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ft206.html
Purity
98.40
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(C)N=C2S1)N)N[C@@H]3CC4=CC=C(N5CC6NC(CC6)C5)C=C4CC3
Molecular Formula
C25H29N5OS
Molecular Weight
447.60
References & Citations
[1]WO2020033707|[2]Diep YN, et al., Astrocytic scar restricting glioblastoma via glutamate-MAO-B activity in glioblastoma-microglia assembloid. Biomater Res. 2023 Jul 19;27 (1) :71.|[3]Ruiz EJ, et al., USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. Elife. 2021 Oct 12;10:e71596.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138698/FT206-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138698/FT206-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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