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FP-Biotin

FP-biotin is a potent organophosphorus toxicant, well-suited for searching for new biomarkers of organophosphorus toxicants exposure. FP-Biotin quantifies FAAH, ABHD6, and MAG-lipase activity. FP-biotin is used for studies with plasma because biotinylated peptides are readily purified by binding to immobilized avidin beads[1][2][3].

Product Specifications

CAS Number

259270-28-5

UNSPSC

12352005

Target

FAAH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/fp-biotin.html

Purity

99.84

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=P(F)(CCCCCCCCCC(NCCCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)=O)OCC

Molecular Formula

C27H50FN4O5PS

Molecular Weight

592.75

References & Citations

[1]Schopfer LM, et al. Reaction kinetics of biotinylated organophosphorus toxicant, FP-biotin, with human acetylcholinesterase and human butyrylcholinesterase. Chem Res Toxicol. 2005;18 (4) :747-754.|[2]Baggelaar MP, et al. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. ACS Chem Biol. 2017;12 (3) :852-861.|[3]Grigoryan H, et al. Covalent binding of the organophosphorus agent FP-biotin to tyrosine in eight proteins that have no active site serine. Chem Biol Interact. 2009;180 (3) :492-498.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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