Necroptosis-IN-5
Necroptosis-IN-5 (Compound 26) is an orally active necroptosis inhibitor. Necroptosis-IN-5 also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1) . Necroptosis-IN-5 can be used to study necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers[1].
Product Specifications
UNSPSC
12352005
Target
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/necroptosis-in-5.html
Smiles
CC1=CC=C(OCCN2CCOCC2)C=C1C3=CC=NC(NC(C4=NN5C([C@@H](F)C[C@H]5C6=CC=CC=C6)=N4)=O)=C3
Molecular Formula
C30H31FN6O3
Molecular Weight
542.60
References & Citations
[1]Jin Z, et al. Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors. RSC Med Chem. 2024 Jun 21;15 (7) :2514-2526.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
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