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Necroptosis-IN-5

Necroptosis-IN-5 (Compound 26) is an orally active necroptosis inhibitor. Necroptosis-IN-5 also exhibits potent inhibitory activity against receptor-interacting protein kinase 1 (RIPK1) . Necroptosis-IN-5 can be used to study necroptosis-related inflammatory diseases, neurodegenerative diseases, and cancers[1].

Product Specifications

UNSPSC

12352005

Target

Necroptosis; RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/necroptosis-in-5.html

Smiles

CC1=CC=C(OCCN2CCOCC2)C=C1C3=CC=NC(NC(C4=NN5C([C@@H](F)C[C@H]5C6=CC=CC=C6)=N4)=O)=C3

Molecular Formula

C30H31FN6O3

Molecular Weight

542.60

References & Citations

[1]Jin Z, et al. Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors. RSC Med Chem. 2024 Jun 21;15 (7) :2514-2526.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

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