TRC051384

TRC051384 is a potent inducer of heat shock protein 70 (HSP70) . TRC051384 exhibits protective effects against neuronal trauma via inhibition of necroptosis. TRC051384 can be used for the research of ischemic stroke[1][2].

Product Specifications

CAS Number

[867164-40-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/TRC051384.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NC1=CC=C(C(/C=C/C2=NC(N3CCOCC3)=CC=C2)=O)C=C1)NCCN4CCOCC4

Molecular Formula

C25H31N5O4

Molecular Weight

465.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Mohanan A, et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. Neuropharmacology. 2011 May;60 (6) :991-9.|[2]Chen T, et, al. HSP70 attenuates neuronal necroptosis through the HSP90α-RIPK3 pathway following neuronal trauma. Mol Biol Rep. 2023 Sep;50 (9) :7237-7244.