AC-4-248

AC-4-248 is an atypical non-competitive dopamine transporter (DAT) inhibitor and reduces the potency of cocaine to inhibit DAT. AC-4-248 is a non-selective inhibitor of SLC6 transporters with IC50 values for hDAT, hSERT, and hNET of 45.5 μM, 96.2 μM, and 250 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Dopamine Transporter

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ac-4-248.html

Smiles

ClC1=CC=C(NC2=C3CCN(CCCNC(CCC)=O)C2)C3=C1

Molecular Formula

C18H24ClN3O

Molecular Weight

333.86

References & Citations

[1]Clara Nautrup Pedersen, et al. Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site. J Neurochem. 2024 Jul 15.