Indirubin-3′-oxime
Indirubin-3′-oxime (IDR3O), a synthetic derivative of indirubin, is a potent inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3β (GSK3β) . Indirubin-3′-oxime directly inhibits the activity of all three isoforms of JNK (JNK1, JNK2, and JNK3), with IC50s of 0.8 μM, 1.4 μM, and 1.0 μM, respectively. Indirubin-3′-oxime can enhance height growth via activation of Wnt/β-catenin signaling in chondrocytes[1][2][3].
Product Specifications
CAS Number
667463-82-3
Product Name Alternative
IDR3O; I3O
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
CDK; GSK-3; JNK; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/indirubin-3-oxime.html
Purity
99.10
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O/N=C1C2=C(C=CC=C2)NC\1=C3C4=C(C=CC=C4)NC\3=O
Molecular Formula
C16H11N3O2
Molecular Weight
277.28
Precautions
H228, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β; JNK1; JNK2; JNK3
Available Sizes
Frequently Asked Questions
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