Anti-Hu NKp80 Purified

NKp80, also known as CLEC5C or KLRF1, is a type II transmembrane glycoprotein of the C lectin family, which is expressed in 80 kDa homodimers on NK cells, and subsets of CD8+ alpha/beta T cells, and gamma/delta T cells. It belongs to the activating coreceptors, which induce cytotoxicity, and production of pro-inflammatory cytokines. Its ligand AICL is expressed on myeloid cells.

Product Specifications

Certification

RUO

Negative Species

Mouse,Rat

Reactivity

Human, Monkey

Immunogen

Recombinant human NKp80 extracellular domain

Target Antigen

NKp80

Clone

5D12

Applications

FC (QC tested), IP

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Dennehy KM, Klimosch SN, Steinle A: Cutting edge: NKp80 uses an atypical hemi-ITAM to trigger NK cytotoxicity. J Immunol. 2011 Jan 15;186 (2) :657-61., URL: https://pubmed.ncbi.nlm.nih.gov/21149606/, *Campbell TM, McSharry BP, Steain M, Russell TA, Tscharke DC, Kennedy JJ, Slobedman B, Abendroth A: Functional paralysis of human natural killer cells by alphaherpesviruses. PLoS Pathog. 2019 Jun 13;15 (6) :e1007784, URL: https://pubmed.ncbi.nlm.nih.gov/31194857/, *Rückrich T, Steinle A: Attenuated natural killer (NK) cell activation through C-type lectin-like receptor NKp80 is due to an anomalous hemi-immunoreceptor tyrosine-based activation motif (HemITAM) with impaired Syk kinase recruitment capacity. J Biol Chem. 2013 Jun 14;288 (24) :17725-33., URL: https://pubmed.ncbi.nlm.nih.gov/23609447/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody 5D12 recognizes an extracellular epitope of human NKp80 (CLEC5C), a C-type lectin family member, expressed on NK cells and subsets of T cells.