Vps34-IN-4

Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].

Product Specifications

CAS Number

[1383716-46-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; PI3K

Type

Reference compound

Related Pathways

Autophagy; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vps34-in-4.html

Purity

99.19

Solubility

DMSO : 78 mg/mL (ultrasonic)

Smiles

CC(O)(C)CNC1=NC=C(C2=NC(NC3=CC=NC=C3)=NC=C2)C(CC4CC4)=N1

Molecular Formula

C21H25N7O

Molecular Weight

391.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7 (1) :72-76.