Bisphenol F

Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260) [1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[620-92-8]

Product Name Alternative

BPF; 4,4'-Dihydroxydiphenylmethane

UNSPSC

12352005

Hazard Statement

H315, H317, H319, H361, H401, H411

Target

Akt; Apoptosis; GSK-3; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/4-4-dihydroxydiphenylmethane.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C(CC2=CC=C(O)C=C2)C=C1

Molecular Formula

C13H12O2

Molecular Weight

200.24

Precautions

H315, H317, H319, H361, H401, H411

References & Citations

[1]Huang M, et al. Bisphenol A and its analogues bisphenol S, bisphenol F and bisphenol AF induce oxidative stress and biomacromolecular damage in human granulosa KGN cells. Chemosphere. 2020 Aug;253:126707. |[2]García-Recio E, et al. Effects of bisphenol F, bisphenol S, and bisphenol AF on cultured human osteoblasts. Arch Toxicol. 2023 Jul;97 (7) :1899-1905.|[3]Maćczak A, et al. Bisphenol A, bisphenol S, bisphenol F and bisphenol AF induce different oxidative stress and damage in human red blood cells (in vitro study) . Toxicol In Vitro. 2017 Jun;41:143-149. |[4]Drobna Z, et al. Bisphenol F has different effects on preadipocytes differentiation and weight gain in adult mice as compared with Bisphenol A and S. Toxicology. 2019 May 15;420:66-72.|[5]Kim Y, et al. Mechanism of Bisphenol F Affecting Motor System and Motor Activity in Zebrafish. Toxics. 2023 May 24;11 (6) :477.|[6]Li B, et al. Effect of bisphenol F on reproductive function in F1 generation male mice and its potential mechanisms. Environ Pollut. 2025 Feb 15;367:125546.|[7]Lv Z, et al. In vivo hypoglycemic effects of bisphenol F exposure in high-fat diet mice. Chemosphere. 2023 Jan;311 (Pt 1) :137066. |[8]Moon HJ, et al. Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice. Anim Cells Syst (Seoul) . 2023 Oct 11;27 (1) :260-271.