ABBV-712
Product Specifications
UNSPSC Description
ABBV-712 is a selective inhibitor of Tyrosine kinase 2 (TYK2), with IC50 of 0.195 μM, that play important role in autoimmune diseases[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/abbv-712.html
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O
Molecular Weight
452.50
References & Citations
[1]Eric Breinlinger, et al. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J Med Chem. 2023 Oct 26;66(20):14335-14356.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156409/ABBV-712-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156409/ABBV-712-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2368945-27-9
Available Sizes
Curated Selection
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