ABBV-712

ABBV-712 is a selective and orally active inhibitor of Tyrosine kinase 2 (TYK2) . ABBV-712 has EC50 values of 0.01, 0.19, and 0.17 μM for TYK2 JH2, TYK2 cells and human whole blood, respectively. ABBV-712 has anti-inflammatory activity and can be used in the research of autoimmune diseases[1].

Product Specifications

CAS Number

[2368945-27-9]

UNSPSC

12352005

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/abbv-712.html

Purity

99.94

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O

Molecular Formula

C24H28N4O5

Molecular Weight

452.50

References & Citations

[1]Eric Breinlinger, et al. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J Med Chem. 2023 Oct 26;66 (20) :14335-14356.