P2Y2R/GPR17 antagonist 1
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist with IC50 values of 3.17 µM and 1.67 µM against P2Y2R and GPR17, respectively. P2Y2R/GPR17 antagonist 1 shows excellent metabolic stability in human liver microsomes[1].
Product Specifications
CAS Number
2395016-49-4
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/p2y2r-gpr17-antagonist-1.html
Concentration
10mM
Purity
98.09
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C=CC=C1)Cl)NC2=CC=C(C=C2)S(=O)(OC3=CC([N+]([O-])=O)=CC=C3)=O
Molecular Formula
C19H13ClN2O6S
Molecular Weight
432.83
References & Citations
[1]Pillaiyar T, et al. Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17. Eur J Med Chem. 2020 Jan 15;186:111789.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y2 Receptor
Available Sizes
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