Imiloxan (hydrochloride)
Imiloxan (RS 21361) hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride produces a dose-related reversal of Guanoxabenz -induced maximal mydriasis in male rats. Imiloxan hydrochloride has the potential for acute kidney injury research[1][2][3].
Product Specifications
CAS Number
81167-22-8
Product Name Alternative
RS 21361
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/imiloxan-hydrochloride.html
Purity
98.47
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CCN1C=CN=C1CC2OC3=CC=CC=C3OC2.Cl
Molecular Formula
C14H17ClN2O2
Molecular Weight
280.75
References & Citations
[1]A D Michel, et al. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99 (3) :560-4.|[2]Takaomi Shimokawa, et al. Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through α2C-adrenoceptors in rats. Eur J Pharmacol. 2016 Jun 15;781:36-44.|[3]Berridge TL, et al. alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system. Br J Pharmacol. 1983 Mar;78 (3) :507-15.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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