BMS-932481
BMS-932481 is an orally active modulator for γ-secretase, selectively reduce Aβ1-42 and Aβ1-40 production, with IC50s of 6.6 and 25.3 nM, respectively[1].
Product Specifications
CAS Number
1263871-36-8
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-932481.html
Solubility
10 mM in DMSO
Smiles
CNC1=C(CC[C@H]2C3=CC=C(F)C=C3)C2=NC(NC4=CC=C(N5N=C(C)N=C5)C(OC)=C4)=N1
Molecular Formula
C24H24FN7O
Molecular Weight
445.49
References & Citations
[1]Toyn JH, et al., Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects. J Pharmacol Exp Ther. 2016 Jul;358 (1) :125-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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