CDK4/6-IN-21
CDK4/6-IN-21 (compound I-52) is a CDK4/6 inhibitor with IC50 values of 3.88 and 3.31 nM for CDK4 and CDK6, respectively. CDK4/6-IN-21 has antitumor activity[1].
Product Specifications
CAS Number
2102887-41-0
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-21.html
Smiles
FC1=C(C2=CC3=C(N=C(C)N3C4CC4)C(F)=C2)N=C(NC5=CC=C(CN(CCN(C)C)CC6)C6=N5)N=C1
Molecular Formula
C27H30F2N8
Molecular Weight
504.58
References & Citations
[1]Guangxin Xia J, et al. Nitrogen-containing fused heterocyclic compound, as well as preparation method, intermediate, composition and application thereof. WO2017114512A1. 2017-07-06.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6
Frequently Asked Questions
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