ERK5-IN-1
ERK5-IN-1 is a potent ERK5 inhibitor with an IC50 of 87±7 nM. ERK5-IN-1 also inhibits LRRK2[G2019S] with an IC50 of 26 nM.
Product Specifications
CAS Number
[1234479-76-5]
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H335
Target
ERK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ERK5-IN-1.html
Purity
99.55
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C2=C(C=CC=C2)N(C)C3=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=NC=C3N1C
Molecular Formula
C25H29N7O2
Molecular Weight
459.54
Precautions
H315, H317, H319, H335
References & Citations
[1]Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6 (11H) -ones. Eur J Med Chem. 2013;70:758-767.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK5
Available Sizes
Curated Selection
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