Emlenoflast
Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of [1][2].
Product Specifications
CAS Number
[1995067-59-8]
Product Name Alternative
MCC7840
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mcc7840.html
Purity
98.19
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=S(C1=NN(C(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O
Molecular Formula
C19H24N4O3S
Molecular Weight
388.48
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25 (23) :5533.|[2]O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
Curated Selection
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