Echitamine (chloride)

Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC50 of 10.92 μM[1][2].

Product Specifications

CAS Number

[6878-36-0]

Product Name Alternative

Ditaine (chloride)

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/echitamine-chloride.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C([C@@]([C@@](C1=CC=CC=C1N2)(CC3)[C@]2([C@H]4O)[N+]3(C/C5=C/C)C)([C@H]5C4)CO)OC.[Cl-]

Molecular Formula

C22H29ClN2O4

Molecular Weight

420.93

References & Citations

[1]Ganesh Chandra Jagetia, et al. Evaluation of the Cytotoxic Effect of the Monoterpene Indole Alkaloid Echitamine In-Vitro and in Tumour-Bearing Mice. J Pharm Pharmacol. 2005 Sep;57 (9) :1213-9.|[2]Ginson George, et al. Development and Validation of a New HPTLC-HRMS Method for the Quantification of a Potent Pancreatic Lipase Inhibitory Lead Echitamine From Alstonia scholaris. Nat Prod Res. 2019 Dec 24;1-5.