Lu AF21934

Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an EC50 of 500 nM for mGlu4 receptor[1].

Product Specifications

CAS Number

[1445605-23-1]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Lu_AF21934.html

Purity

99.99

Solubility

DMSO : ≥ 80 mg/mL

Smiles

O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2

Molecular Formula

C14H16Cl2N2O2

Molecular Weight

315.20

Precautions

H315, H319, H335

References & Citations

[1]Anna Sławińska, et al. Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu? receptor. Neuropharmacology. 2013 Mar;66:225-35.|[2]Ossowska K, et al. Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats. Neuropharmacology. 2014 Aug;83:28-35.|[3]Anna Sławińska, et al. The antipsychotic-like effects of positive allosteric modulators of metabotropic glutamate mGlu4 receptors in rodents. Br J Pharmacol. 2013 Aug;169 (8) :1824-39.