Monastrol

Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.

Product Specifications

CAS Number

[329689-23-8]

Product Name Alternative

(±) -Monastrol

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Kinesin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Monastrol.html

Purity

99.89

Solubility

DMSO : ≥ 33 mg/mL

Smiles

O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC

Molecular Formula

C14H16N2O3S

Molecular Weight

292.36

Precautions

H302, H315, H319, H335

References & Citations

[1]Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280 (13) :12658-67.|[2]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389 (12) :1279-1288.|[3]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286 (5441) :971-4.