Monastrol
Product Specifications
UNSPSC Description
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
Target Antigen
Apoptosis; Kinesin
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Monastrol.html
Purity
99.89
Solubility
DMSO : ≥ 33 mg/mL
Smiles
O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC
Molecular Weight
292.36
References & Citations
[1]Cochran JC, et al. Monastrol inhibition of the mitotic kinesin Eg5. J BiolChem. 2005 Apr 1;280(13):12658-67.|[2]Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288.|[3]Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101071A/Monastrol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101071A/Monastrol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
329689-23-8
Available Sizes
Curated Selection
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