MELK-8a
Product Specifications
UNSPSC Description
MELK-8a (NVS-MELK8a) is a highly potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor with IC50 of 2 nM. MELK-8a also inhibits Flt3 (ITD), Haspin, PDGFRα with IC50s of 0.18, 0.19, and 0.42 μM, respectively. MELK plays an essential role in regulating cell mitosis in a subset of cancer cells[1].
Target Antigen
Haspin Kinase; MELK; PDGFR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/melk-8a.html
Purity
98.32
Solubility
DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CN(CC1)CCN1C2=CC=C(N3C=C(C4=CC=NC=C4OCC5CCNCC5)C=N3)C=C2
Molecular Weight
432.56
References & Citations
[1]B Barry Touré, et al. Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight. J Med Chem. 2016 May 26;59(10):4711-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100368/MELK-8a-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100368/MELK-8a-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1922153-17-0
Available Sizes
Curated Selection
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